Regulation of transposable elements by DNA modifications

Cross-Regulation between Transposable Elements and Host DNA Replication

Transposable elements subvert host cellular functions to ensure their survival. Their interaction with the host DNA replication machinery indicates that selective pressures lead them to develop ancestral and convergent evolutionary adaptations aimed at conserved features of this fundamental process. These interactions can shape the co-evolution of the transposons and their hosts.

Epigenetic regulation of Mammalian genomes by transposable elements.

Transposable element (TE) sequences make up a substantial fraction of mammalian genomes and exert a variety of regulatory influences on mammalian genes. We explore the contributions of TEs to the epigenetic mechanisms that regulate mammalian genomes, emphasizing nucleosome positioning and epigenetic histone modifications. A link between TEs and epigenetics rests on the fact that underlying gene...

Regulation of Metastasis and DNA Damage Resistance Pathways by Transposable Elements

Perspective : Transposable Elements , Parasitic Dna , and Genome

The nature of the role played by mobile elements in host genome evolution is reassessed considering numerous recent developments in many areas of biology. It is argued that easy popular appellations such as ‘‘selfish DNA’’ and ‘‘junk DNA’’ may be either inaccurate or misleading and that a more enlightened view of the transposable element-host relationship encompasses a continuum from extreme pa...

Transposable Elements: No More 'Junk DNA'

Since the advent of whole-genome sequencing, transposable elements (TEs), just thought to be 'junk' DNA, have been noticed because of their numerous copies in various eukaryotic genomes. Many studies about TEs have been conducted to discover their functions in their host genomes. Based on the results of those studies, it has been generally accepted that they have a function to cause genomic and...